Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0356668
PubChem CID
Molecular Formula
C22H30NO4+
Molecular Weight
372.485 g/mol
Synonyms/Alias
[N-Me-laudanosine; N-methyl-laudanosine; CHEMBL215370; CHEMBL1182154; BDBM50199404; 1-(3;4-Dimethoxy-benzyl)-6;7-dimethoxy-2;2-dimethyl-1;2;3;4-tetrahydro-isoquinolinium iodide; 1-(3;4-Dimethoxy-benzy...
InChI Key
RVBHVIRGZXRPRX-SFHVURJKSA-N
InChI
InChI=1S/C22H30NO4/c1-23(2)10-9-16-13-21(26-5)22(27-6)14-17(16)18(23)11-15-7-8-19(24-3)20(12-15)25-4...
IUPAC Name
(1S)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2,2-dimethyl-3,4-dihydro-1H-isoquinolin-2-ium
CAS Number
64228-81-5

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

27 29 0 0 0 0 0 0 0 0999 V2000
1.3951 -0.6763 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
0.2428 -1.6366 0.0000 N 0 0 0 0 0 4 0 0 0 0 0 0
-0.5115 -2...

Experimental Data

Activity Data

Target Ion Channel
Small conductance calcium activated potassium channel protein 1/2/3
Uniprot Accession Number
Function
Blocker
Species
Rattus norvegicus (Rat)
IC50
IC50: 1295 nM
EC50
N/A (Not available)
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
pH 7.5
Holding Potential
Not specified
Temperature
Room Temperature
Test Method
Binding assay
Test Species
Not specified

Binding Information

Binding Site
Not specified
Binding Site Residue
Not specified

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
27
Rotatable Bonds
6
logP
3.6373
Complexity
106.2164
TPSA (Ų)
36.92
H-Bond Donors
0
H-Bond Acceptors
4
Ring Count
3
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